Antimicrobial activity of marine fungi pdf

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The extracts were tested for antibacterial activity. A total of 7 were active towards Vibrio parahaemolyticus and 55 towards Staphylococcus aureus, representing 18 different fungal species from 8 ascomycetous genera.

For 61 strains of Penicillium citrinum antibacterial activity correlated well with content of secondary metabolites as measured by HPLC. Thirteen isolates of Penicillium steckii produced very similar profiles of secondary metabolites and 6 of these had activity against either V.

Moreover, organisms were mainly collected in lagoons Only very little information is available concerning and mangroves presenting ecological niche systems antimicrobial activities of isolates of marine-derived expected to furnish optimal conditions for the discov- fungi. Cuomo et al. The organisms were grown crobial activities from cultures of marine isolates on two media differing in nutrient content and the to cultures of terrestrial fungi. It was concluded combined extracts assayed for antibacterial activity by that a higher number of antimicrobial active species the well diffusion method.

Moreover, since marine species are not well investigated more new biologically active compounds Materials and methods were secured than from terrestrial. The production of antimicrobial metabolites from slow-growing marine Collection of samples and preparation of isolates fungi was investigated by Newman et al.

Probably due to the slow reproductive cycle of these organ- Samples were collected at Mochima Bay, Mochima isms, the activity in some instances was dependant National Park and Paria Bay, Irapa, both in the Su- on growth conditions, e. A total of eight cultures were investigated. Voucher specimens of all The marine-derived fungi so far investigated do not fungi isolated are kept at the Department of Biotech- include ubiqituous genera as Aspergillus and Penicil- nology, The Technical University of Denmark and at lium.

Isolates active against Vibrio parahaemolyticus VP and each sample was deposited in a sterile plastic bag Staphylococcus aureus SA. Each sample was numbered, a Species Number of strains Activity description recorded and the location and water tem- Tested Active towards perature noted.

Samples were kept cold until returned Alternaria sp. Gliocladium roseum 1 1 SA The chloramphenicol solution, which was stored cold, Penicillium citrinum 61 29 SA contained chloramphenicol Sigma 0. The chlorotetracycline solution consisted of Penicillium phoeniceum 11 3 VP chlorotetracycline Sigma 0. Only one of the active strains listed water ml and trace metal solution 1 ml. After in Table 1 A. The trace metal solution consisted of the same medium.

Agar Agar 0. The inoculated plates were the samples were applied to the plates. When growth appeared were shaken with sterile saline 0.

The plates were kept in perforated plastic bags for 5 days at room temperature and the isola- Preparation of extracts for HPLC analysis and tion was initiated. Plates without growth or with only activity testing small colonies were monitored for fungal growth for the following days.